New research indicates that patients who come off blockbuster slimming jabs like semaglutide or tirzepatide may regain shed pounds far faster than those who stop conventional diet and exercise regimens.
Findings released in a leading health publication shows that while obese people frequently drop substantial amounts of their total mass while using the jabs, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals purchasing such treatments should be aware of the risk of rapid rebound weight gain when the medication ends," cautioned expert Dr. Susan Jebb.
Such speed of recovery means a return to pre-treatment mass in about one and a half years.
Comparing Therapies
The study, which examined 37 of trials involving over 9,000 of patients, compared the effects of the injectable medications with other pills.
The team emphasize that individuals who lose weight through dieting generally see a slower weight regain—perhaps 0.1 kg a month—post-intervention.
Understanding the Quick Regain
Nutrition scientists propose the mode of action of the drugs accounts for the heightened regain.
The injections imitate a natural hormone called GLP-1, which moderates hunger.
"Artificially providing the hormone levels far above than the body's typical production may cause the system to produce less of its own natural GLP-1, and could lessen responsiveness to its actions," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication leads to appetite is uncontrolled, making overeating a significant risk."
A Chronic Condition?
The NHS advise the injections for people with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Professionals contend that, considering the high risk of relapse, the treatment should be considered long-term.
This opinion is reinforced by pharmaceutical companies, who state that the results "underscore the persistent nature of obesity," similar to managing diseases like diabetes.
User Experiences
Users who have come off the jabs report a sudden return of appetite.
"It felt as if something flipping and I was suddenly extremely hungry," described a patient.
This challenge is exacerbated if users have not established permanent lifestyle or habit changes during treatment.
Growing Use
Survey data suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with interest continuing to grow.
- Adoption is greater among women compared to males.
- The middle-aged age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than public health services.
Ultimately, experts caution that while these medications are powerful agents for weight loss, they are not a permanent solution and long-term success likely depends on ongoing behavioural changes.
